Yes most defiently.
You could have multiple inputs including your turntable and run your towers as your 2 main speakers which is how it normally done anyway and then when playing your records just use these 2 towers and the sub.
I have an ARCAM AVR 600 and use the 2 larger speakers (Focal Electras 1027s)and the sub ( JL Audio f110) as my 2 channel play back and run the room equalizer program for this setup. I also have the option to use the other channels for surround dialog if I wanted to use them later on.
This receiver that your eyeing has the sub out and even a phono stage input so if you buy the said speakers you will be all set.
You still need a sub to get the most out of your system and the on board menu settings of the receiver will Help you tweek the sound for the different inputs.
I hope this helps.